The first US Navy destroyer to be lost in combat was the USS Jacob Jones, sunk by the German submarine SM U-53 6 December, 1917. The ship's brief history, and its loss- the only US destroyer lost during the great war- represented the risks faced by, and heroism of, the men of the US Navy in that war.
In September, 1918, two desperate battles unfolded over two consecutive days between lightly armed American Naval vessels and the same German Submarine.