The first US Navy destroyer to be lost in combat was the USS Jacob Jones, sunk by the German submarine SM U-53 6 December, 1917. The ship's brief history, and its loss- the only US destroyer lost during the great war- represented the risks faced by, and heroism of, the men of the US Navy in that war.
During the civil war, the manufacture of powder and explosives was often handled by the most vulnerable, young women and children, whose labor was needed when so many men had been sent off to war. On March 13, 1863, the confederacy experienced a munitions disaster, in the confederate capitol of Richmond.